Endocrine Abstracts

Within the pituitary, GnRH acts via type I GnRH receptors to cause a Gq/11 mediated activation of PLC and consequent acute stimulation of gonadotrophin secretion and chronic regulation of gonadotrophin and GnRHR synthesis. The therapeutic effects of GnRH analogues are primarily (if not entirely) dependent upon activation, desensitisation or blockade of this system. There is also abundant evidence for expression of GnRHRs in extra-pituitary sites including the CNS, t...